Yes. I’ve used trap and release traps for mice found in the home. I filled the small openings outside using a steel wool type material I got through Amazon for keeping mice out. Inside, under kitchen sinks…where the pipes are, the openings are pretty wide and are easy access for rodents. Close those up, too. Also, bathrooms and anywhere in your house where there are gaps. I release the mice at least three miles away in an open, wildlife refuge where there are no homes. I read that they can find their way back if not released far enough. I would never use poisons or anything toxic. There are predators that’ll eat dead animals…such as bald eagles, for example…that will ingest the poison of their prey and get very sick or die. Also, using lead sinkers in fishing and lead bullets in hunting can be dangerous, too. They eat a lot of fish and carrion. Think of the food chain in the wild, overall.